5-Amino-1MQ (5-Amino-1-Methylquinolinium) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that consumes both NAD+ precursors and the methyl donor SAM. By blocking NNMT, 5-Amino-1MQ has been researched for its effects on white adipose tissue metabolism, fat oxidation, muscle stem cell preservation, and overall metabolic flexibility.
Unlike the peptide products in the AxonChems catalog, 5-Amino-1MQ is a small molecule (not a peptide) and is orally bioavailable, making it suitable for both injectable and oral research preparations. Research has focused on obesity-resistant metabolic phenotypes, aged muscle stem cell function, and methyl donor preservation in metabolic studies.
Molecular Formula: C10H11N2 (cation form, typically supplied as iodide salt C10H11N2I) Molecular Weight: 159.21 Da (cation); 286.11 Da (iodide salt) CAS: 13441-69-7 (iodide salt)
Mechanism: Selective inhibitor of NNMT, blocking the methylation of nicotinamide to 1-methylnicotinamide (MNA). This preserves both the NAD+ salvage pool (via nicotinamide recycling) and the SAM methyl donor pool.
Storage: Lyophilized at 2-8°C, protect from light and moisture. Reconstituted: refrigerate and use within 30 days.
Purity: ≥99% HPLC. Third-party COA included. Research use only. Not for human consumption.
